@Coote, I think ADI should have elaborated a bit better for you.
Anecdote: with a mild load of 2205 and CCI 300's in a 16" 44 Mag, I got globs of unburned powder in the barrel and glowing lumps of it shooting downrange. It took a near max load, a firm crimp, and a CCI 350 before the powder really started doing what it was supposed to.
There's got to be enough sustained heat and pressure in the chamber/barrel to get a powder going properly and sustain the burn, if you want to get the most out of it. So... Will powders ignite with standard primers? Yes, definitely... Is the affect on pressure (i.e. of a magnum primer) that ADI alluded to sometimes necessary to help create the circumstances for certain powders to perform properly in certain applications? Also yes.
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