Greetings @Kelton and all,
To belatedly address your OP I loaded my .22 Hornet using Dupont IMR4227 and the Hornady 45 grain projectile back in thvery early 1980's. The rifle has had an extended period of safe curing but lately I have been thinking of getting it going again. The max loads in the Hodgdon data for IMR4227 has been reduced substantially over the years and Hodgdons Lil'gun has emerged as the go to powder for velocity in the Hornet. I used 10.5 grains of IMR4227 which at the time was a mid load but the max is now 9.8 grains although at lower pressure. I suspect that that the reduction is due to some of the weaker rifles chambered for the Hornet. You can look at the load data on the Hodgdons site.
Regards Grandpamac.
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