I dont think anyone will argue that a 243 win is better than a 338. I like my 338 Norma a lot and obviously its first call for genuine long range but the little 243ai is a lot easier to carry, shoot, load for and in the right conditions its very effective. Not for beginners but 500yds isnt for beginners with any cartridge.
But really the OP was asking a specific question and wasn't trying to start a which is best thread.
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