Absolutely. Choose the appropriate pill for the range & game you are intending to shoot & place the shot accurately = job done. I run a bush load (140gn Accubond or 145gn Speer HC) and 162 AMAX or ELDMS for 300+. In my 22in bbl 284 I get north of 3000fps running 162s with RL26. Who needs a REM mag?! Get 2950 fps with RL17.
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