The appeal of cast bullets to me is guaranteed availability as long as you can find lead. Current projectile situation is exactly why I like the idea of casting. I also enjoy tinkering and I design my own bullets and machine my own molds.
The smaller caliber high velocity cartridges just don't work that well with cast projectiles for larger game and to me a .30 is about as small as you can go and still get decent weight behind a reasonable length projectile.
The fact that you also have a speed limit of around 2200fps adds to the need for weight. 140-160gr seems to perform well at this velocity and it so happens that you can achieve this out of a little case like a 300 HAM'R, thumbs up all round in my books.
Subs are interesting and I have a short 45-70 single shot that I am loading cast 450gr flat nose projectiles at 1050fps which is great fun, but the trajectory and sights limit it to inside 100m realistically.
I have enough high velocity high BC laser beams that can kill to 800m+, cast bullets are the other end of the spectrum and is its own challenge, which I enjoy.
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