I kinda come from the school of... accuracy first allowing for excellent bullet placement, then enough speed and frangibility or expansion to do the business. As we can't expect copper and lead to be a smart bullet making up for our own shortcomings in where the bullet goes and the terminal damage delivered.
That said I've always had good results for longer shots with the 208 amax's and now Eld's. With another round with similar POI 0-200yds like a Barnes or GMX in the chamber for the reaction shot. (eliminating the chance of bullet break up at close ranges, but still enabling you to set up and cycle the action for the round below for a long shot)
Recently for long range gong shooting and because the 208's and heavier rounds can, and do beat you up over a long day I've been using the Berger Hunting VLD's starting with 195's before dropping down to the 175's which go very well and consistently for me.
I've heard people say the best round is the one you are most comfortable and confident in using ... I think there's a lot of wisdom in that..
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