Currently, Benchmark 8208 for 100gr and up, and Benchmark 2 for anything under. I'm also going to try SMP 763 with 130's once the range re-opens. H335 has also worked very well for me in the past.
I've had one Grendel that would show pressure signs when approaching anything close to max, and another that scoffs at "max" and begs for more powder. I suspect subtle variations in chamber design (Grendel has been through a couple of iterations) play a large part in this. Hence, as with any cartridge, but especially this one, you should absolutely be doing your own workup.
Both mine were/are 20". Whilst some point out that the faster powders finish burning in much shorter barrels and they get acceptable speeds, the pressure curve is still accelerating the bullet beyond the point where combustion finishes, so having more barrel still helps eek out the maximum potential of the cartridge (or at the very least gets those same acceptable speeds with less pressure).
IMO, this is important with Grendel, depending on what you want to use it for, because unlike say a short barrelled 308 - which will still lob bullets with enough speed/energy to put stuff down cleanly well beyond the limit of the average shooters ability, say 400-500m - Grendel's effective range on larger game is already less than that. So the more speed you can retain, the more you'll find yourself limited by what you can do vs what the cartridge can.
Keep it as long as you can
Edit. Nosler Ballistic Tips for hunting, any day of the week.
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