I have done subs in my 243. However i have a 1:8 barrel. loaded a 105gr to sub sonic with trail boss. Don't have my load data book on me just now but if interested I can find it for you.
Accuracy was OK given the range. Only shot 1 goat with it, went in the front, tumbled and came to rest under the skin at the rump.
I have stopped with them at that point in the 243. (Would probably just use a lighter bullet with a minimum charge)
I do still carry some in my 35 calibre for that final finishing shot or but find I have settled upon a mix of 3 loads.
Full power for general shooting, low power (full charge of trailboss) light bullet (pistol) for short range bush shooting without silencer 1500-1800 fps etc and subs for finishing shots, goats, possums etc
Z
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