2208 probably isn't the best choice for top speeds in 223. It's relatively slow burning and there's not enough case capacity to get as much as you'd like in there.
How lenient are max loads? Interesting. Well, the moment you change so much as one thing from the published recipe, whether that's the primer, the brand of brass, the seating depth, chamber dimensions, powder lot... anything... you will have changed the pressure a bit. So the "true" max charge will be a bit different.
So yeah there is some leniency but it's impossible to say how much in your scenario. Working up and watching for pressure signs is all you can do.
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