Storage can be a problem with nitroglycerin tablets used under the tongue for angina - the volatile nitroglycerin content of the tablets migrated, so tablets and bottom and top had different potency, meaning a poor shelf life. Nowadays it is less of a problem with nitroglycerin tablets as they are individually blister packed.
If you have a double base powder (which contains nitroglycerin), consider shaking it up to ensure it's well mixed so the powder at top and bottom has uniform nitroglycerin content.
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