The process of working out a load seems to be pretty much the same for every cartridge. Delving into wildcats and ackley improved cartridges adds a bit of entertainment, as it adds in forming or fireforming the brass to the process.
I've certainly had rifles that have been challenging but not really cartridges. Little idiosyncrasies like bedding issues, barrels that aren't free floated, nasty triggers, bad crowns... things that unless you catch will have you going around in circles and none of which have anything to do with the cartridge.
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