Thread: Large vs small

Yes
With all the usual caveats regarding reloading and variations in rifles. Noted difference are.....

SRP

Needs more powder to get same Vel

Can be harder to ignite (you can get hang fires)

Gives lower SD and ES

Gives more reloads per case (depending on your reloading regime)

Is it worth the change and subsequent load development? It does let you swap to what's available, but if a lot of people change then availability goes away as well.
Right now to change runs the chance of component substitution that could outweigh any benefits.

I run Rem 7 1/2 BR's for a hotter ignition flame, others will tell you they don't need to. Some people have to have their firing pin bushed.
Every situation is different.