Also, look at timing of shots, an over-warm barrel can significantly open up groups, if the first two are close and the third is a flier, may just need some more space. I find that shooting lots in quick succession is better for replicating grip etc, but very bad for warm barrel.. A fan can also speed up cooling.
Are you using a muzzle device? if not, could also be a flinch and/or just jumpy recoil. could also check its not coming loose after 2 shots if you already are.
if you are sure its the load, then best to work it up from scratch. not overly hard to do if you follow a systematic process.
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