As a(very) general rule stick to the middle weights for your caliber. except monolithic projectiles like Barnes and hornady gmx which you can go lighter to get speed up because they work best at higher velocitys and out penetrate conventional bullets.
with the exception of some target and long range hunting bullets bullets like amax berger to name just a couple generally heavy bullets are more stoutly constructed and are not perhaps the best choice for our thin skinned light big game.
bullet terminal performance is affected mainly by
bullet construction and impact velocity.
out to 300y your not goin to have a huge impact velocity difference So I would be inclined to run a lightish for caliber bullet at higher speed than a heavy for flatter trajectory.
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