I get 2560 fps with 42.5 of 2208 from a 24 inch barrel, same bullet.
I have used 2208 and 2206 (the original, not 2206h). Published data suggested 2206 better for lighter projectiles, 2208 better for heavy pills. The only significant difference I found was when I pulled the projectiles on some old reloads - the 2208 looked normal, the 2206 was caked inside the cases.
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