A case full of 2208 (about 24.5 to 25.0 grains) behind a Sierra 65 Gn will be about as good as you'll get with 2208 (its a bit slow for 223 unless using very heavy projectiles). It'll be kinda slow (about 2650-2700) but will be a very effective killer out to 250M and these "full case loads" of 2208 usually shoot well. As always work up from 10% less.
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