It can make a big difference.
If you load up a batch and seat 5 projectiles at 10, 20, 30, 40 etc thou off the lands you will see big differences on paper over the range of seating depths.
Best to work a promising load with different charge weights (working up) then play with seating depth than try to alter both at the same time. Too many variables can get complicated and frustrating.
You can also load up test loads at a set charge weight and shoot groups at different depths then alter charge weight slightly either side to see if you can tighten groups up.
Lots of ways to do it.
Enjoy and good luck.
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