Pretty much. You are limited on velocity so have to make up for it with mass and frontal area to get the terminal effect. And you only need a tiny bit of powder to send a bullet out at 1000fps so if you have a large case it needs stuffing with something like trail boss to take up the space. Otherwise the velocities can end up all over the place.
So something like a 243 with a little 6mm bullet and 45gr of case capacity doesn't make much sense as a subsonic cartridge and would be difficult to get consistent.
Whereas a 300 blackout, 45acp, 450 bushmaster, 8.6 blackout are either naturally subsonic or don't need to be significantly down-loaded to make them so (to the point of becoming erratic), and have much bigger harder hitting bullets. Some of which are made to give some expansion at subsonic speeds.
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