Unless every shot is going to be a clean bore shot in the field, you need to know how it will shoot with a fouled bore, so yes.
3-5. 3 if it's a rifle I know shoots well and I'm shooting lots of groups which together will give a bigger picture. Then probably a 5 to confirm.
Let it cool between each shot, especially with lighter barrels. Otherwise if you get a bad group you don't know whether it's because the load's no good or because heat screwed it up.
100. Or further, if the range allows.
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