Not Zimmer, but I shot with a 22.250 for a while. For shots through the ribs or on small animals I found the 50 grain BT worked fine, but the best deer load I used was the 70 grain Speer SP. I never recovered a bullet on anything I shot, and it did the business on some big reds.
As a bonus, it shot to the same POI @100 as the 50 BT's and later 55 VMax.
From memory it was pushed by a fair spoonful of N160, and did 3400.
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