Front on shot is harder than it looks. Base of neck, hydraulic shock the spinal cord and get it on the ground - hard - even if it isn't an immediately fatal hit. The best option is taking out the central comms harness, combined with hydraulic shock - next best is tear out the plumbing and bleed the thing out. This will shut down the brain and the processing bits and also bleeding the muscles out and removing the blood is the best option for meat quality.
If you look at the size/layout of the central organs from the front on perspective (very narrow side to side and quite deep), they are really arranged in a very difficult to hit manner and the other possibility is the bullet striking bone and deflecting out away from the vitals (the rib cage is almost purpose built for this if you consider sparring stags and the tine points going somewhere they aren't supposed too...).
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