Based on seeing reasonable number of animals hitting the deck(no wolverines) from various calibers and a wide range of shooting abilities.
Whether you think so or not, adrenaline and testosterone makes stags harder to kill. Some breeds have an absolute desire to live (try Rusa).
If you don't believe adrenaline makes a difference poke a shot though a non vital part of a Cape Buffalo and then try to kill him.
I haven't experienced it, but know people who have and they swear it's not something they wlsh to repeat.
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