Get to know the makeup up a bull's head, and where the weak spots are (behind ear when quartering away from you, in through ear canal when side on, etc etc). Then make sure you are happy at being very accurate with the intended load. Just blazing away in behind the front shoulder on a big animal will fill the meat with adrenaline.
Go for the "dropped like a sack of spuds" shot, and get up there pronto and bleed it out
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