It means you won't be able to use the high bc 69gr plus options.
There's still plenty of good options for killing deer that will work in the slow twist. The 50gr (approx) monos, 60gr nosler partition, 70gr speer or simple 55/60gr soft points of various brands.
If you're after a very flat shooting rifle with absolutely minimal recoil and aren't going to push the range then the .22-250 will be awesome. If you're looking for an option with the ability to push the range and shoot high bc projectiles with still light recoil I'd look at the .243 as the better option, the Sakos will be a 8 twist which should allow you to shoot 100+gr high bc projectiles. Recoil with a suppressor will be very similar to heavy .22-250 loads.
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