Its probably been covered, but most 22-250 are 1/14 twist which limits them in bullet weight. I had one and it wouldn't stabilise 60 grn. I shot the barrel out using 55 grn at 3,500fps on hares, goats and deer.
A 22-250 and 55 grn projectiles is no better on deer than a .223 and 55 grn.
A fast twist .223 shooting 75/80 grn bullets at 2,800/2,900 fps eats a 22.250 with 55 grn bullets at 3,500 fps on deer.
A fast twist 22.250 shooting 75/80 grn bullets at 3,300 fps eats a 223 with anything. But a fast twist 22.250 is rare. You are using twice as much powder, increasing the bang, and might just as well step up to a 243 or something bigger.
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