If you intend having a bolt action, I wouldn't bother with the Grendel unless it's going to be youth rifle.
I have an AR15 upper in the calibre, as it's far better than hunting with a .223 AR for knockdown.
Not so good for losing the brass though.
I'm using 123gn SSTs, CFE223 powder and Hornady brass, which I can handle losing more than Lapua.
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