At longer ranges honestly I would stick with the chest shoulder area as the target area, heart, lungs, liver is so much larger.
I've seen a few neck shots work and more that have not worked, either miss or soft tissue hit only, end result is the same as a head shot that hits the jaw it buggers off to die slowly later.
The 22 mag will do the job but there's not much wriggle room at range so maximise your chances and go for the biggest bit. Even when I cull goats today using a 223 or 7.62 x39 I go for the big bit as most are a moving target after shot no 1
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