Yes, there's quite a bit of difference between the different sized models but also the cartridge (gas volume), barrel length (muzzle pressure), and calibre (diameter of exit hole) combined has as big if not a far bigger effect.
20" barrelled 223 with a 13" 35mm suppressor: very nearly if not hearing safe.
20" barrelled 6.5 Grendel with a 9" 50mm suppressor: could shoot that sucker all day long.
18" barrelled 308 with a 9" 35mm suppressor. Won't deafen you on the spot, but say hello to tinnitus in the evening.
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