22 250 or 243 offer the best possibilities. The 22 250 in a fast twist can if you hand load go from 222 performance up and handle the heavier 80 grain bullets if you wish although plenty of deer have fallen over with a 55 grain one, the 243 with the light 55-60 grainers is good for small game and with the 100 grainer is a damn fine deer carfridge.
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