Not really. If you're disciplined and have the opportunity to take well placed head/neck shots, then yes I suppose, otherwise no. I tried subsonic 300BLK (identical to subsonic .308 ballistics) and the factory ammunition offerings are unimpressive, or at least highly variable in performance. Penetration wasn't the problem, expansion was an issue. I also had quite a few rounds going supersonic, so the worst of all worlds. Like you, I thought about a subsonic larger calibre (e.g. 45/70), but they are loud even when suppressed.
It didn't end too badly for me. I resigned myself to using supersonic 300BLK ammunition in my Bergara single shot with a large suppressor. It's a short, relatively quiet rifle that is handy in the bush.
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