Two things I've noticed. Had a full length bedded kimber that shot everything same poi at 100. Heard similar results from the Barret Fieldcrafts which are bedded the same way. So that may be an option if you wanted simplicity.
Otherwise I run factory, handloads and subs through one gun. And just have the offsets set in hornady 4dof.
Also when I run subs I marked the dial where my 50 yard and 100 yard zeros where. Seems to work good. Although I only ever run a super and sub load combo in a hunt not 2 super loads
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