No issues at all other than if you forget to account for the offset or swtich loads back and forget to un-offset.
Do you actually have the two loads or are you intending to develop a long range load?
From experience chances are the zero for each load will be very close anyway that it may be a non issue.
Also from experience it may not actually be worth the hassle running two different loads, I'd want some seriously imporved performance to risk the shooter error this could bring.
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