Yes. Wynns EDT is my go to - it's a biocide and solvent/cleaner with added lubricity stuff. I use it regularly with my ranger, as it had a dose of bug in the past which was uncovered as part of other investigative work (and unfortunately threw the mechs off the scent for what was actually the issue, also weird as I was only filling off commercial retail suppliers).
In the past I've had a rough running Hyundai Tucson, went through some investigation and mechs were saying pull injectors blah blah. A mate said what have you got to lose - try some mechanic in a bottle... I had the EDT through running it in the boat to keep the bug from getting into it so went what the hell? Had a nearly empty tank, chucked a tank full's worth of EDT 'treatment dose' in and went down the road to fill up. I didn't get 2Km down the road before the rough running was gone, replaced by silky smooth much quieter and more responsive diesel engine noises - no more knocking or farting about. Had the same thing on other engines too...
So yes, the additives can work and work well but in some cases they can also create an issue if there is a lot of crap in the system by loosening up debris and moving it into somewhere it shouldn't be. Also, if you have a mechanical issue and the problem isn't related to crap in the works the cleaners won't work and can make the problem worse by removing more stuff from worn injector and the like. It won't fix injector patterns if the injector nozzle is chewed out is another way of looking at it.
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