A well placed shot with a lower energy projectile is often a cleaner kill than a poorly placed shot carrying higher energy, particularly with non-jacketed projectiles that don't deform enough to release their energy in the first place.
My recommendation with a .22LR at 100m is don't worry so much about the energy, and focus on accuracy - test a bunch of different ammo and use what is most accurate in your rifle. Work out your maximum 'minute of rabbit' distance based on your grouping and stick to that max range. Most of my .22's will shoot CCI standard velocity into 1/2 the group size of the extreme speed stuff at 100m. That said, I personally limit my .22LR range to 75m on rabbits.
I made up a life size rabbit target for testing. Printed on A4 paper this is pretty much spot on. It has the vital kill zones circled. To work out your max effective range, you need to be able to get 100% of your rounds grouped into either of the kill zones.
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