My two cents for fun... I have no experience with 257 nor 22-250. But my experience with .25-06, while I used to think it was an awesome calibre, I've seen and heard too many deer get away, even with very well placed shots (i.e. Straight through both third ribs).
If reading between the lines of ego and preference from some of you, I pick out the crucial differences between the cartridges, it seems to me the 257 typically travels a bit slower and therefore packs a bit more punch, more successfully putting deer on the deck.
I've had similar experiences with my old .308 where I'm now fairly convinced that projectiles travelling in excess of 3000fps are going too fast to generate the internal trauma required to put a large animal down so it stays down. These days I prefer my 6.5x55 because I'm yet to see any animal get up from a 140g SPBT, and I've recovered the last three mushroomed projectiles from my last three deer, with two of those just under the skin on the far side of bullet entry. My projectiles are doing 2560fps at the muzzle.
Each to their own of course, but my unfounded love of super velocity calibres like .25-06 and .22-250 died quite some time ago.
If I was long range target/varmint shooting however...hmmm
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