Any slope either up or down will require less hold over. 45 degrees in theory will halve your drop. shooting straight up (not recommended) or straight down, no drop at all.
Remember bullet drop is due to gravity and exerts it's maximum effect when shooting perfectly level.
Have a play with Hornady's ballistic calculator on their website. You could enter the details of your above example to see if that accounted for your POI change.
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