Yes the .450 has the potential to shoot 400gr subs.
The targeting I focus on with subs is shooting for the central nervous system. And that doesn’t need much in the way of brute force. I’d far rather knock the animal over, then quickly push a finisher into it, than have to go looking for it. For close range hunting, I’ve found the .308 151gr really accurate out to ~80m (as far as I’ve tested) and for high shoulder shooting it’s very effective - in through the upper shoulder blade, into the spine around the T2-3-4 vertebrae and out the other side. It’s quite a big target. At sub-25m I’ve shot a range of animals... flyblown sheep, dozy billy goats, an injured horse to bailed pigs, all in the head or top of the neck.
No doubt in my mind that the .308 subsonic is a far better option for precision shooting than the other rifle I use with subs, a Ruger 77/44 (.44 Rem Mag).
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