Both will work well - when I was choosing my hunting rifle I looked at both, I went with the Ruger American Predator in 6.5cm over the Howa. I liked the trigger, the magazines (gen 2) are compatible with my Ruger Precision as well, its light and every review I'd seen said they are tack drivers - now owning one I can confirm that. It is true that the Ruger is a bit rougher around the edges - but functionally they are awesome - Magpul hunter stocks are available if you wanted to upgrade that (stock is probably the weakest point). I havent got any experience with the .450 so can't comment to much, although you might consider the .350 legend as an option there as well.
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