I have used a 50 zero on occasion, as you say the point blank zero is slightly extended but not significantly so. For my 223 The so called zeros are at 50 and 125 but the trajectory only peaks at .3 inches above them at 75 yards which is margin of error stuff.
Parallax on a non adjustable scope introduces an error at that range as most scopes without it are set to be parallax free at 100. Changing scope height above bore has a significant effect also. Verification is always an excellent practice if you can do it. It is also quite instructive to shoot a tall target without ajusting the sight as you change range that way you can determine the actual drops and adjust any ballistic calculator values with confidence.
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