Originally Posted by
rugerman
There is no guarantee any dog you get wont have health problems, so getting a pure bred dog doesn't really make a difference. Certain breeds are "known" as having certain problems, but of course that doesn't mean that another breed wont have the same or different problems so you really just have to roll the dice. Hybrid vigour is sometime used to describe the benefits of having a mixed breed which does better than the pure bred parents, but as mentioned this does not mean the mixed breed pup wont get whatever afflicts the parents.
As for a dog or bitch, as Micky mentioned a non desexed bitch will drop a bit of blood around the place every now and again and sometimes her milkshake can bring the boys to the yard so there is that to consider. I've had both sexes and as long as they are trained properly then handling them is pretty similar really.
As BlackFern says, there are a heap of breeders around who are only into it for the money and couldn't give a crap about how healthy any pups are as long as they make lots of money. Smallish puppy farms are all over the place where someone has a few bitches and just keep breeding to make money ( one of the reasons I turned down an offer of a lab pup from a similar place).
Visit the pups parents if you can so you can see what sort of condition they are living in and to make sure any pups have been socialized from an early age otherwise you will have an uphill battle trying to train them if they don't know how to act like a dog.