.22-250, your best bet would be a .357 Smith & Wesson 686 or 586, second-hand in good condition. S&W are the best made revolvers, and the older models (15+ years) are better made than the new ones. Rugers are OK but very agricultural in the trigger pull, and the sights are only fair. Dan Wesson are just bloody awful. Most modern revolvers are made from investment castings which are OK and certainly strong enough, but lacking the fit and finish to give smooth action. The newer S&W do have some investment cast parts but the older ones are drop forged and machined which gives greater strength and a smoother finish. An older S&W .357 with a good barrel will have good accuracy and 158 grain hollow-point loads will do most things properly for you without being difficult to shoot.
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