55gr Gameking softpoints have worked good on fallow. Actually have more drop on the spot kills with this than 130gr interlock 270s on the smaller deer inside 250 meters.
Have also shot big wap/red Cross Hinds that had escaped from farms and the 22/250 worked well.
I always aim behind the shoulder, have drifted forward and clipped the shoulder blade with no real problems however if you wanted to aim for shoulder shots I'd go to a mini or bonded projectile.
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