Pretty much the only downside is fireforming brass and you can't use it for shoots that only allow 223 (not that many).
Supposedly once fireformed brass prep in non-existent.
The extra 100-150fps should be enough to get 85-90gr bullets up near 2800fps with a decent length barrel.
For a competition rifle I think it'd be worthwhile (subject to class restrictions), general plinking/hunting probably not.
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