I have had two 22-250, both used for varmints and dogs (coyotes)in canada, have taken coyote's to 450m, with my old browning HB (sako action) safari.
There a great cal, but if you realy want to reach out a bit, get a 1-10 twist or faster, (browning and savage now make them) and run a 75gr a-max at 3400 fps, lots of fun, sold both mine thought, I kept my 6mm remington, bit more flexable,
guys above have summed up the 22-250 well.
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