Culling vs Freezer filling - only difference should be the use for the meat afterwards, with culling there's no such thing as overkill since you aren't concerned about meat damage. We should always be trying for clean kills - sometimes things don't go right, that's going to happen but we should always try and avoid it. Using a caliber within its limitations be it size of game or range is just decency really. A rim fire is much more likely to wound an animal the size of a goat or bigger - it may survive injured or die freaking slowly from infection - a center fire with a suitable hunting projectile even if it isn't the best shot will likely kill the animal sooner and more humanly. I know full well that anything could be killed with a 22LR but you need a well placed shot within a suitable distance and the margin for error is pretty small.
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